Each pigment is different. Some are eye safe, but not lip or body safe. Normally, when you buy a pigment, it comes with an insert in the box that lets you know. Here's a link that also lets you know what pigments are eye, lip and/or body safe (as well as Paints, CCBs, and glitters). It doesn't appear to be completely up-to-date, but you can always call MAC CS regarding specific colors.