Hm, I seem to be the opposite of most. I find that while synthetics are incredicbly soft, they don't pick up powders as well as natural. I started off using synthetics and it never picked up the powder so I always had to apply everything wet, but then I started using natural brushes as omg everything applied so much better (however they are more scratchy). I see this mostly in mineral foundation. I started off using a synthetic set (kabuki, powder, blush brushes) but once I switched to natural flat top, the foundation actually gets picked up int eh brush a lot more and then onto my skin, and blush application has been a drastic change. I always thought there was a problem with my blushes because they never showed until after many many layers, but with a natural brush, I only need a tiny bit of product.